Effects of Ginsenoside Rb1 Loaded Films on Oral Wound Healing

This study aimed to evaluate the effects of two ginsenoside Rb1 (G-Rb1) loaded films on oral wound healing. Two types G-Rb1 films, carboxymethyl cellulose (GCMC) film and hyaluronic acid (GHA) film, were developed. A total 36 Sprague-Dawley rats divided into 3 groups: control, GCMC, GHA. After formation midpalate, control group was left without treatment, whereas experimental groups had attached. The specimen analyzed clinically histologically after 7 21 days. For clinical analysis, area incompletely re-epithelialized measured. histological distance between margins (soft tissue gap) measured percentage collagen-stained calculated. In soft gap GCMC presented improved healing compared GHA at day (<i>p</i> < 0.05). And, both (9.74 ± 10.12%) (19.50 14.47%) greater collagen-positive pixels (0.89 1.60%) However, there no differences in these parameters among 21. Therefore,